| Title | A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Fröhlich, R. F. G., Fantur K., Furneaux R. H., Paschke E., Stütz A. E., Wicki J., Withers S. G., and Wrodnigg T. M. |
| IRL Team | Carbohydrate Chemistry |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 21 |
| Pagination | 6872-6875 |
| ISSN | 0960894X |
| Keywords | 5 dideoxy 1, 5 imino dextro galactitol, article, beta galactosidase, chaperone, controlled study, diagnostic imaging, drug activity, drug determination, enzyme inhibition, fibroblast, galactitol, GM1 gangliosidosis, iminosugar, in vitro study, lysosome associated membrane protein 2, n (dansylamino)hexylaminocarbonylpentyl 1, structure activity relation, tracer, unclassified drug |
| Abstract | N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol, a strong competitive inhibitor of β-galactosidase, enhances residual β-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant β-gal as well as aberrant GM1 gangliosides by live cell imaging. © 2011 Elsevier Ltd. All rights reserved. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-80054760142&partnerID=40&md5=1fe2b98e525bbde5c7bcea3a63c31520 |
| DOI | 10.1016/j.bmcl.2011.09.012 |
