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Wound healing and tissue repair
IRL’s revolutionary bioactives have wide-ranging applications involving natural products in tissue repair and chronic wound healing. Our proprietary bioactives interact with and control the physiological processes involved in wound healing and offer cost-effective wound healing alternatives to current high-cost technologies. By identifying compounds that target multiple aspects of each phase of wound healing, a product can be formulated to assist throughout the healing cascade.
View the TVNZ7 Innovation Stories programme on IRL's wound healing work with manuka honey producer, Comvita. The IRL science contribution comes from Drs Ian Sims and Susie Carnachan in Carbohydrate Chemistry, and was co-published with ComVita in: G. STEINHORN, I.M. SIMS, S.M. CARNACHAN, A. CARR and R. SCHLOTHAUER, Isolation and Characterisation of Arabinolalactan-proteins from New Zealand Kanuka Honey, Food Chemistry, 128 (2011) 949-956.
Human skin cells. IRL's novel bioactives involve natural products in tissue repair and the healing of chronic wounds.
Demonstrated ability
- Identification of a cryptic protein that supports blood supply to wounds
- Identification of several novel phytochemicals with bio-activity including cranberry juice antimicrobials, passion fruit anti-asthmatic and grapefruit pro-angiogenic compounds
- Experience with N-acylethanolamines – natural long chain fatty amides which may act as signalling and cell-protective molecules.
We also have experience in related areas such as enzymatic processing, fermentation and pilot scale bioreactors, and production of high-value lipids.
Key expertise
- Bioactives identification (expertise in protein/peptide, flavonoid and polysaccharide-based bioactives relating to wound healing and tissue repair)
- Extracellular matrix scaffolds for tissue regeneration
- Assay development and consultancy
- Tissue scaffold analysis
- GAG[?] analysis (HA, CS, HS and Heparin)
- ELISA quantification of growth factors and cytokines
- Extraction and analysis of elastin, collagens and matricellular proteins
- Extracellular matrix protein (ECM) isolation and analysis
- Amino acid analysis
- Peptide sequencing LC-MS[?]/MS
- Enzyme assays relevant to wound care
- Product analysis and independent testing
- Formulation development and medical device prototyping
- Bioactive enzymatic modification to improve bio-availability and efficacy
- Lipid analysis
- Medical device regulatory pathway 510(k).