| Title | Rapid synthesis of 1-deoxygalactonojirimycin using a carbamate annulation |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Timmer, M. S. M., Dangerfield E. M., Cheng J. M. H., Gulab S. A., and Stocker B. L. |
| IRL Team | Carbohydrate Chemistry |
| Journal | Tetrahedron Letters |
| Volume | 52 |
| Pagination | 4803-4805 |
| Keywords | annulation reaction, article, carbamic acid, chemical structure, migalastat, piperidine, synthesis |
| Abstract | A remarkably efficient synthesis of the biologically important iminosugar 1-deoxygalactonojirimycin (DGJ) is presented. Key to this strategy is the development of a novel carbamate annulation reaction that favours formation of a six-membered carbamate-containing piperidine skeleton over its five-membered counterpart. © 2011 Elsevier Ltd. All rights reserved. |
| URL | http://www.scopus.com/inward/record.url?eid=2-s2.0-80051684974&partnerID=40&md5=8e1abcb7dcea07b444e2775e34c2fba6 |
| DOI | 10.1016/j.tetlet.2011.07.044 |
